Cagrilintide 5mg/10mg|10vials
Price range: $103.00 through $299.00
Cagrilintide is a synthetic peptide compound intended exclusively for laboratory research use. It is supplied in lyophilized powder form for controlled in vitro studies performed by qualified professionals.
This is a cyclic peptide composed of 38 amino acids, with a sequence containing 38 amino acids and a pair of disulfide bonds. Kaglirin can significantly reduce weight and reduce food intake. Kagrelin peptide has potential in obesity research.
As a non selective amino acid receptor (AMYR) and calcium G protein coupled receptor (CTR) advocate, Cagrinide is a new long acting acetylated amino acid analysis, which is a cyclic peptide composed of 38 amino acids The sequence contains a pair of defective bonds Cagritide can significantly reduce weight and food intake Cagritide has potential in objectivity research.
Description
Cagrilintide is a novel long-acting amylin analog featuring N-terminal lipidation that extends its half-life by binding to albumin. This synthetic peptide mimics and enhances natural amylin’s effects, simultaneously targeting multiple metabolic and appetite regulation pathways in both homeostatic and hedonic systems.
Weight Management and Obesity Efficacy
Clinical trials have demonstrated that cagrilintide effectively reduces body weight in individuals with obesity. In a phase 2 trial, cagrilintide led to greater weight reductions compared to placebo and liraglutide, with the highest dose achieving a mean weight reduction of 10.8%1.
When combined with semaglutide, cagrilintide showed enhanced weight loss and improved glycaemic control in individuals with type 2 diabetes2. A meta-analysis of RCTs also showed that this combination (CagriSema) resulted in significantly greater weight loss compared to semaglutide alone8.
Comparative Studies
Cagrilintide has been compared to other dual amylin and calcitonin receptor agonists (DACRAs) like KBP-336. While both show efficacy in weight loss and glucose control, KBP-336 has demonstrated superior long-term efficacy in preclinical models, suggesting differences in receptor activation balance3.
Combination therapies involving cagrilintide and other agents like tirzepatide have shown promising results in enhancing weight loss and reducing food intake, highlighting the potential for combinatorial approaches in obesity management4.
Cardiovascular Health
Amylin-based therapies, including cagrilintide, are being investigated for their potential cardiovascular benefits, such as vasodilatory, anti-inflammatory, and anti-atherosclerotic effects. These therapies are scrutinized for their impact on blood pressure, lipid profiles, and cardiovascular markers. Amylin analogs may offer innovative approaches to enhance metabolic and cardiovascular health, potentially reducing the global burden of cardiovascular diseases5.
Glycemic Control
Cagrilintide controls hyperglycemia through various actions. In a phase 2 trial of obese patients with type 2 diabetes, CagriSema reduced glycated hemoglobin (HbA1c) levels. At 32 weeks, the reduction in HbA1c levels with CagriSema was statistically superior to cagrilintide alone, but not statistically greater than semaglutide6. Another study combining semaglutide and cagrilintide found that CagriSema improved glycemic control7.
Additional information
| Content per Kit | 5mg, 10mg |
|---|---|
| Packing (Vials) | 1kit, 10kits, 50kits, 100kits |
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